In this chapter, we provide evidence that perfectionism should be viewed as a vulnerability factor of importance in suicide and present a model of perfectionism and suicide that reflects the importance of interpersonal perfectionistic behavior. Our conceptual and empirical analysis is based on the hypotheses that (a) trait perfectionism dimensions are vulnerability factors linked directly with suicide and (b) trait perfectionism is linked indirectly with suicidal tendencies via its association with life stress and social disconnection. In subsequent sections of this chapter, we report results of research that investigates the link between perfectionism and suicide in a variety of populations. These findings highlight how socially prescribed perfectionism is a particularly robust factor in suicidality.